DNA nanotechnology is the design and manufacture of technologically useful macromolecules using nucleic acids, the building blocks of DNA. In living cells, DNA is the carrier of genetic information. In the lab, strands of nucleic acids can spontaneously bind to form strong, rigid double helix structures with precisely controlled nanoscale features. Two- and three-dimensional crystal lattices, nanotubes, polyhedra, and various functional devices have been created. Tiles of nucleic acids can be assembled into larger units. Artificial DNA structures have been used to solve basic science problems in structural biology, biophysics and X-ray crystallography, and have helped identify protein structures through nuclear magnetic resonance spectroscopy. Potential applications in molecular scale electronics and nanomedicine are being investigated. The conceptual foundation for DNA nanotechnology was first laid out by Nadrian Seeman in the early 1980s, and the field began to attract widespread interest in the mid-2000s. (Full article...)
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