October 19: Mother Teresa Day in Albania
- 1469 – Ferdinand II of Aragon married Isabella I of Castile (both pictured), a marriage that paved the way to the unification of Aragon and Castile into a single country, Spain.
- 1864 – American Civil War: Despite incurring nearly twice as many casualties as the Confederates, the Union Army emerged victorious in the Battle of Cedar Creek.
- 1900 – German physicist Max Planck produced his law of black body emission, a pioneer result of modern physics and quantum theory.
- 1943 – Streptomycin, the first antibiotic remedy for tuberculosis, was first isolated by researchers at Rutgers University.
- 1986 – President of Mozambique Samora Machel and 43 others were killed when his presidential aircraft crashed in the Lebombo Mountains just inside the border of South Africa.
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